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Thirty years ago, cord blood stem cell transplants were considered experimental. Today they have become a standard of care for the treatment of more than 80 diseases. For some diseases, cord blood is deployed when all other therapies have failed. For others, cord blood/stem cell transplants are the only recognized therapies that provide curative treatment. Whether you are storing cord blood for your child’s sake or that of a family member, making this decision could be one of the most important things you can do to ensure health and longevity.
Below are the current diseases that are recognized as standard treatments in the United States:
| Diagnosis |
| Acute Lymphoblastic Leukemia (ALL) |
| Acute Myelogenous Leukemia (AML) |
| Acute Biphenotypic Leukemia |
| Acute Undifferentiated Leukemia |
| Chronic Lymphocytic Leukemia (CLL) |
| Chronic Myelogenous Leukemia (CML) |
| Juvenile Chronic Myelogenous Leukemia (JCML) |
| Juvenile Myelomonocytic Leukemia (JMML) |
| Diagnosis |
| Refractory Anemia |
| Refractory Anemia with Ringed Sideroblasts (Sideroblastic anemia) |
| Refractory Anemia with Excess Blasts |
| Refractory Anemia with Excess Blasts in Transformation |
| Chronic Myelomonocytic Leukemia (CMML) |
| Diagnosis |
| Hodgkin's Lymphoma |
| Non-Hodgkin's Lymphoma (Burkitt's Lymphoma) |
| Diagnosis |
| Anemias are deficiencies or malformations of red cells |
| Aplastic Anemia |
| Fanconi Anemia - (The first cord blood transplant in 1988 was for FA, an inherited disorder) |
| Congenital Dyserythropoietic Anemia |
| Paroxysmal Nocturnal Hemoglobinuria (PNH) |
| Inherited Red Cell Abnormalities - Red cells contain hemoglobin and carry oxygen to the body |
| Sickle Cell Disease |
| Beta Thalassemia Major (aka Cooley's Anemia) |
| Diamond-Blackfan Anemia |
| Pure Red Cell Aplasia |
| Inherited Platelet Abnormalities - Platelets are blood cells needed for clotting |
| Amegakaryocytosis / Congenital Thrombocytopenia |
| Glanzmann Thrombasthenia |
| Inherited Immune System Disorders: Severe Combined Immunodeficiency |
| SCID with Adenosine Deaminase Deficiency (ADA-SCID) |
| SCID which is X-linked |
| SCID with absence of T & B Cells |
| SCID with absence of T Cells, Normal B Cells |
| Omenn Syndrome |
| Inherited Immune System Disorders: Neutropenias |
| Infantile Genetic Agranulocytosis (Kostmann Syndrome) |
| Myelokathexis |
| Inherited Immune System Disorders: Other |
| Ataxia-Telangiectasia |
| Bare Lymphocyte Syndrome |
| Common Variable Immunodeficiency |
| DiGeorge Syndrome |
| Hemophagocytic Lymphohistiocytosis |
| Leukocyte Adhesion Deficiency |
| Lymphoproliferative Disorders |
| Lymphoproliferative Disorder, X-linked (Susceptibility to Epstein-Barr virus) |
| Wiskott-Aldrich Syndrome |
| Myeloproliferative Disorders |
| Acute Myelofibrosis |
| Agnogenic Myeloid Metaplasia (Myelofibrosis) |
| Polycythemia Vera |
| Essential Thrombocythemia |
| Phagocyte Disorders - These are immune system cells that engulf and kill foreign organisms |
| Chediak-Higashi Syndrome |
| Chronic Granulomatous Disease |
| Neutrophil Actin Deficiency |
| Reticular Dysgenesis |
| Bone Marrow Cancers |
| Multiple Myeloma |
| Plasma Cell Leukemia |
| Waldenstrom’s Macroglobulinemia |
| Diagnosis |
| Cartilage-Hair Hypoplasia |
| Erythropoietic Porphyria |
| Hermansky-Pudlak Syndrome |
| Pearson's Syndrome |
| Shwachman-Diamond Syndrome |
| Systemic Mastocytosis |
| Diagnosis |
| Mucopolysaccharidosis (MPS) Storage Diseases |
| Hurler Syndrome (MPS-IH) |
| Scheie Syndrome (MPS-IS) |
| Hunter Syndrome (MPS-II) |
| Sanfilippo Syndrome (MPS-III) |
| Morquio Syndrome (MPS-IV) |
| Maroteaux-Lamy Syndrome (MPS-VI) |
| Sly Syndrome (MPS-VII) (beta-glucuronidase deficiency) |
| Mucolipidosis II (I-cell Disease) |
| Leukodystrophy Disorders |
| Adrenoleukodystrophy (ALD) |
| Krabbe Disease (Globoid Cell Leukodystrophy) |
| Metachromatic Leukodystrophy |
| Pelizaeus-Merzbacher Disease |
| Lysosomal Storage Diseases |
| Niemann-Pick Disease |
| Sandhoff Disease |
| Wolman Disease |
| Other Inherited Metabolic Disorders |
| Lesch-Nyhan Syndrome |
| Osteopetrosis |
| Diagnosis |
| Neuroblastoma |
| Medulloblastoma |
| Retinoblastoma |
Data taken from: http://parentsguidecordblood.org/diseases.php
